Open AccessVaginal misoprostol in managing premature rupture of membranes
Author(s) -
Ibrahim Ayad
Publication year - 2002
Publication title -
eastern mediterranean health journal/eastern mediterranean health journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.442
H-Index - 47
eISSN - 1687-1634
pISSN - 1020-3397
DOI - 10.26719/2002.8.4-5.515
Subject(s) - misoprostol , medicine , gestation , obstetrics , premature rupture of membranes , oxytocin , prostaglandin e1 , bishop score , prostaglandin e2 , cervical dilatation , rupture of membranes , pregnancy , gynecology , cervix , abortion , biology , genetics , cancer
We compared the efficacy of misoprostol with that of prostaglandin E2 in cervical ripening and labour induction. Thus 238 women with rupture of membranes beyond 36 weeks gestation without labour were randomized to receive 50 microg misoprostol vaginal gel or 5 mg of prostaglandin E2 gel. Bishop score was evaluated before drug application and 6 hours later. Clinical data and perinatal outcome were recorded. Mean time from induction to delivery and the need for oxytocin were significantly less in the misoprostol group. There were no significant differences in spontaneous labour rate, type of delivery and perinatal outcome. It is concluded that intravaginal misoprostol is safe and more effective than prostaglandin E2 for preinduction cervical ripening in premature rupture of membranes beyond 36 weeks gestation.