Open AccessAppraisal of sickle-cell and thalassaemia genes in Saudi Arabia
Author(s) -
Mohsen A. F. ElHazmi,
Arjumand S. Warsy
Publication year - 1999
Publication title -
eastern mediterranean health journal/eastern mediterranean health journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.442
H-Index - 47
eISSN - 1687-1634
pISSN - 1020-3397
DOI - 10.26719/1999.5.6.1147
Subject(s) - gene , thalassemia , population , cell , sickle cell anemia , hemoglobinopathy , medicine , beta thalassaemia , genetics , biology , environmental health , hemolytic anemia
A comprehensive national survey of the distribution of the sickle-cell [Hb S]gene and thalassaemia genes was initiated in 1982, with more than 30, 055 blood samples collected. The Hb S, alpha- and beta-thalassaemia gene frequency range was 0.005-0.145, 0.01-0.40 and 0.01-0.15 respectively in various areas of Saudi Arabia. We present here an appraisal of sickle-cell and thalassaemia gene occurrence in the Saudi population, based on our studies conducted over 10 years in different regions of Saudi Arabia