Open AccessPrevalence of hepatitis C virus RNA in patients with chronic renal diseases
Author(s) -
Olfat Shaker,
H. Aboul Fadl,
Mohamed Khaled El Hatw
Publication year - 1998
Publication title -
eastern mediterranean health journal/eastern mediterranean health journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.442
H-Index - 47
eISSN - 1687-1634
pISSN - 1020-3397
DOI - 10.26719/1998.4.3.548
Subject(s) - medicine , gastroenterology , virus , hepatitis c virus , etiology , chronic renal failure , kidney disease , immunology
The prevalence of hepatitis C virus [HCV] RNA in 80 patients with chronic renal diseases was determined. Two sets of primers from the non-coding region of the hepatitis C virus were used. The products [188 bp] amplified by polymerase chain reaction were visualized by 2% agarose gel electrophoresis stained with ethidium bromide. The patients were classified into four groups. Group I comprised 40 adult patients with end-stage renal disease, 31 of whom were positive for HCV-RNA [77.5%] ; group II, 22 children with glomerulopathies, 15 of whom were positive [68.2%] ; group III, 9 children with chronic renal failure of unverified etiology, 6 of whom were positive [66.6%] ; group IV, 9 children with chronic renal failure due to obstructive uropathy of whom 3 [33.3%] were positive. We conclude that HCV may infect a high percentage of patients with chronic renal failure or renal parenchymatous disease