Open AccessCellular immune response in acute hepatitis B leading to chronic carrier state
Author(s) -
Mona Morsi,
S. Zaki,
Muhammad Umar Kamal,
S. A. Sadaka,
Y. M. El Shimy
Publication year - 1997
Publication title -
eastern mediterranean health journal/eastern mediterranean health journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.442
H-Index - 47
eISSN - 1687-1634
pISSN - 1020-3397
DOI - 10.26719/1997.3.2.322
Subject(s) - hbcag , hbsag , immune system , medicine , immunology , antigen , cellular immunity , interferon , chronic hepatitis , interferon gamma , interleukin 2 , hepatitis b virus , virus
Immunological studies among jaundiced patients revealed significant changes in T-helper and T-suppressor cells among chronic HBV cases from the acute and control groups. The chronic cases revealed a highly significant decrease in interleukin-2R expression but their low interferon-gamma values were statistically nonsignificant from the control group. The acute cases recorded the highest interleukin-2R and interferon-gamma values. Lymphocyte blastogenesis assay in response to different mitogens and antigens produced two groups:responders [acute cases] and nonresponders [chronic cases]. The responders revealed more intact specific and nonspecific cellular immune responses. Neither group differed with regard to their proliferative response to HBsAg, but vigorous response to HBcAg was a significant feature of the responders