Cellular immune response in acute hepatitis B leading to chronic carrier state | Zendy

Mona Morsi | Zendy; S. A. Zaki | Zendy; MOHAMMAD K. KAMAL | Zendy; S. A. Sadaka | Zendy; Y. M. El Shimy | Zendy

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Cellular immune response in acute hepatitis B leading to chronic carrier state

Author(s) -

Mona Morsi,

S. A. Zaki,

MOHAMMAD K. KAMAL,

S. A. Sadaka,

Y. M. El Shimy

Publication year - 1997

Publication title -

eastern mediterranean health journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.442

H-Index - 47

eISSN - 1687-1634

pISSN - 1020-3397

DOI - 10.26719/1997.3.2.322

Subject(s) - hbcag , hbsag , immune system , medicine , immunology , antigen , cellular immunity , interferon , chronic hepatitis , interferon gamma , interleukin 2 , hepatitis b virus , virus

Immunological studies among jaundiced patients revealed significant changes in T-helper and T-suppressor cells among chronic HBV cases from the acute and control groups. The chronic cases revealed a highly significant decrease in interleukin-2R expression but their low interferon-gamma values were statistically nonsignificant from the control group. The acute cases recorded the highest interleukin-2R and interferon-gamma values. Lymphocyte blastogenesis assay in response to different mitogens and antigens produced two groups:responders [acute cases] and nonresponders [chronic cases]. The responders revealed more intact specific and nonspecific cellular immune responses. Neither group differed with regard to their proliferative response to HBsAg, but vigorous response to HBcAg was a significant feature of the responders

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