Open AccessIn situ characterization of B-and T-lymphocytes in basal cell carcinoma of the head and neck region
Author(s) -
S. A. Saleh,
A. A. El Sissy,
E. M. Ismail
Publication year - 1997
Publication title -
eastern mediterranean health journal/eastern mediterranean health journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.442
H-Index - 47
eISSN - 1687-1634
pISSN - 1020-3397
DOI - 10.26719/1997.3.1.58
Subject(s) - immune system , basal cell carcinoma , pathology , basal (medicine) , head and neck , carcinoma , biology , immunology , basal cell , medicine , endocrinology , surgery , insulin
Twentycases of basal cell carcinoma [BCC] of the head and neck region were examined immunohistochemically for the detection of T- and Blymphocytes. The results showed that the dense lymphocytic infiltrate surrounding neoplastic cells of BCC consisted chiefly of T-lymphocytes. The lymphocytic infiltrate revealed in parts a pattern of a small lymphocytic follicle with peripherally situated T cells and central B cells. The predominance of Tlymphocytes in BCC suggests a local cell-mediated immune response. However, the presence of B-lymphocytes indicates a possible humoral immune reaction. T cells may be responsible for regulating the proliferation, and thus the growth, of malignant epithelial cells in BCC