In situ characterization of B-and T-lymphocytes in basal cell carcinoma of the head and neck region | Zendy

Suleiman Saleh | Zendy; A. A. El Sissy | Zendy; E. M. Ismail | Zendy

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In situ characterization of B-and T-lymphocytes in basal cell carcinoma of the head and neck region

Author(s) -

Suleiman Saleh,

A. A. El Sissy,

E. M. Ismail

Publication year - 1997

Publication title -

eastern mediterranean health journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.442

H-Index - 47

eISSN - 1687-1634

pISSN - 1020-3397

DOI - 10.26719/1997.3.1.58

Subject(s) - immune system , basal cell carcinoma , pathology , basal (medicine) , head and neck , carcinoma , biology , immunology , basal cell , medicine , endocrinology , surgery , insulin

Twentycases of basal cell carcinoma [BCC] of the head and neck region were examined immunohistochemically for the detection of T- and Blymphocytes. The results showed that the dense lymphocytic infiltrate surrounding neoplastic cells of BCC consisted chiefly of T-lymphocytes. The lymphocytic infiltrate revealed in parts a pattern of a small lymphocytic follicle with peripherally situated T cells and central B cells. The predominance of Tlymphocytes in BCC suggests a local cell-mediated immune response. However, the presence of B-lymphocytes indicates a possible humoral immune reaction. T cells may be responsible for regulating the proliferation, and thus the growth, of malignant epithelial cells in BCC

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