Open AccessComparing potential of Ficus carica and Allium sativum on triglyceride to HDL ratio in high fat diet fed male Wistar Albino rats
Author(s) -
Sofia Chandio,
Shahida Hassan Memon,
; María,
Nosheen Zehra Mangi,
Ikram uddin Ujjan,
Ali Raza
Publication year - 2021
Publication title -
sindh university research journal
Language(s) - English
Resource type - Journals
ISSN - 1813-1743
DOI - 10.26692/surj.v53i04.4218
Subject(s) - carica , allium sativum , ficus , hyperlipidemia , cholesterol , lipid profile , biology , triglyceride , blood lipids , traditional medicine , chemistry , botany , medicine , endocrinology , diabetes mellitus
Present study compares the potential of Ficus carica and Allium sativum on triglyceride to HDL ratio in high fat diet fed male Wistar albino rats. A sample of 36 male Wistar albino rats was randomly divided into 6 groups (A, B, C, D, E and F). Hyperlipidemia was induced by high fat diet (HFD) (banaspati ghee + coconut oil) mixed in normal chow diet. After six weeks, blood was taken through retro – orbital capillary plexus, centrifuged to get sera, stored at -20°C temperature for biochemical analysis of blood lipids. TAG/HDLc ratio (atherogenic index of plasma) was measured as log TAG/HDLc. Statistical package (SPSS ver. 21.0, IBM, incorporation, USA) analyzed the results by 1- ANOVA and post – Hoc Benforinni test (p≤ 0.05). Cholesterol, TAGs, LDLc, and HDLc shows significant decrease in F. carica and A. sativum treated experimental groups C – F compared to positive controls (P=0.0001). A. sativum shows more potent hypolipidemic potential and more significant reduction in TAG/HDLc ratio compared to F. carica (P=0.0001). The present study concludes Ficus carica and Allium sativum show hypolipidemic potential with significant decrease in TAG/HDLc ratio and they may be used to prevent atherosclerosis and coronary artery disease as simple home remedy.