Open AccessResearch Progress of Protein Tyrosine Phosphatase Receptor-Type O in Hepatocellular Carcinoma
Author(s) -
Xiangzhe Yang,
Qin Ye,
Xinke Xie
Publication year - 2021
Publication title -
proceedings of anticancer research
Language(s) - English
Resource type - Journals
eISSN - 2208-3553
pISSN - 2208-3545
DOI - 10.26689/par.v5i6.2803
Subject(s) - hepatocellular carcinoma , protein tyrosine phosphatase , cancer research , tyrosine , phosphatase , immunotherapy , medicine , carcinoma , receptor tyrosine kinase , receptor , phosphorylation , biology , cancer , biochemistry
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world with a high incidence and has become one of the most malignant cancers worldwide. Its clinical treatment mainly includes surgical intervention, chemotherapy, and immunotherapy, with poor curative effect and prognosis. In recent years, with the development of basic research, it has been revealed that protein tyrosine phosphatase receptor-type O (PTPRO) plays an important role in the pathogenesis of hepatocellular carcinoma. Protein tyrosine phosphatase receptor-type O is a new type of protein tyrosine phosphatase, which has been proven to inhibit oncoprotein. In this paper, the potential mechanism of protein tyrosine phosphatase receptor -type O in the progression of hepatocellular carcinoma is discussed to provide reference for clinical treatment and drug development.