Open AccessResearch Progress on the Effect of Sphingosine Kinase 2 on Glioma
Author(s) -
Chunpeng Wang,
Xiaohui Liu,
Shiwen Guo
Publication year - 2021
Publication title -
proceedings of anticancer research
Language(s) - English
Resource type - Journals
eISSN - 2208-3553
pISSN - 2208-3545
DOI - 10.26689/par.v5i6.2763
Subject(s) - glioma , sphingosine , cancer research , medicine , downregulation and upregulation , immunohistochemistry , chemistry , biochemistry , receptor , gene
Objective: The purpose of this study is to explore the role of sphingosine kinase 2 (SphK2) in the treatment of glioma, which is the most common primary tumor in the central nervous system. Methods: A total of 82 patients were included in this study, with 27 cases in the control group and 55 cases in the glioma group; the expressions of SphK2 and gp130 in the two groups were compared by immunohistochemical method, and the correlation between the two factors was analyzed. Results: Both SphK2 and gp130 were upregulated in the glioma group, and the two factors were significantly correlated. Conclusion: The high expression of SphK2 may play an important role in the occurrence, development, and diagnosis of glioma.