Open AccessResearch Progress on the Antitumor Mechanism of Compound Kushen Injection
Author(s) -
Yuntao Duan,
Weijian Liang,
Junming Hou,
Dezhen Yang
Publication year - 2021
Publication title -
proceedings of anticancer research
Language(s) - English
Resource type - Journals
eISSN - 2208-3553
pISSN - 2208-3545
DOI - 10.26689/par.v5i5.2511
Subject(s) - angiogenesis , medicine , mechanism (biology) , metastasis , cancer research , apoptosis , chemotherapy , radiation therapy , tumor cells , pharmacology , cancer , biology , philosophy , biochemistry , epistemology
Compound Kushen Injection (CKI), as a clinical traditional Chinese medicine preparation, has prominent antitumor effect but with several side effects. A large number of studies have shown that CKI plays an antitumor role by regulating tumor cell proliferation, inducing tumor cell differentiation and apoptosis, inhibiting tumor cell invasion and metastasis, reducing tumor angiogenesis, regulating the immunity, and so on. Clinically, CKI is widely used to treat various tumors, where it is often combined with surgery, chemotherapy, radiotherapy, targeted therapy, and other antitumor treatments. This article reviews the antitumor mechanism of CKI and the progress of its clinical application in order to provide a theoretical basis for further clinical application.