Open AccessResearch Progress on Molecular Mechanisms of Tumor Budding in Colorectal Cancer
Author(s) -
Qian Li,
Jinmei Li,
Jinku Zhang
Publication year - 2021
Publication title -
proceedings of anticancer research
Language(s) - English
Resource type - Journals
eISSN - 2208-3553
pISSN - 2208-3545
DOI - 10.26689/par.v5i4.2340
Subject(s) - tumor budding , colorectal cancer , cancer research , pathological , budding , biology , cancer , oncology , medicine , pathology , metastasis , genetics , lymph node metastasis
Tumor buds are usually defined as isolated single cancer cells or clusters of up to four cancer cells located at the front of invasive tumors which play an important role in the clinical pathological study of colorectal cancer. The prognostic value of tumor budding in colorectal cancer has been supported by a large amount of evidence. However, its molecular mechanism remains unclear, and it is also a research hotspot now. This paper reviews the latest research progress on the molecular mechanisms of tumor budding in colorectal cancer.