Open AccessMechanism of Protein Tyrosine Phosphatase O Receptor in Hepatocellular Carcinoma
Author(s) -
Qin Ye,
Xinke Xie
Publication year - 2021
Publication title -
proceedings of anticancer research
Language(s) - English
Resource type - Journals
eISSN - 2208-3553
pISSN - 2208-3545
DOI - 10.26689/par.v5i2.1978
Subject(s) - protein tyrosine phosphatase , hepatocellular carcinoma , mechanism (biology) , carcinogenesis , cancer research , tyrosine , phosphatase , inflammation , receptor tyrosine kinase , medicine , biology , receptor , phosphorylation , biochemistry , cancer , philosophy , epistemology
Pathologist Virchow has proposed a hypothesis that the origin of tumors comes from chronic inflammation. Clinically, liver tumors can be divided into three types Hepatocellular carcinoma (HCC) is the most common type, which is closely related to various kinds of inflammation. Studies have shown that protein tyrosine phosphatase receptor type O (PTPRO) is a new type of protein tyrosine phosphatase, which is negatively correlated with tumorigenesis. As a new tumor suppressor protein, PTPRO is of great significance for the diagnosis and treatment of HCC in the future. This paper aims to discuss the mechanism of PTPRO in HCC.