Open AccessResearch Progress of miRNA Regulating Cell Signaling Pathways Related to Hepatocarcinogenesis
Author(s) -
Dan Wang,
Yang Xing-wu,
Guotai Wang
Publication year - 2021
Publication title -
journal of clinical and nursing research
Language(s) - English
Resource type - Journals
eISSN - 2208-3693
pISSN - 2208-3685
DOI - 10.26689/jcnr.v5i2.1921
Subject(s) - microrna , hepatocellular carcinoma , cancer research , metastasis , signal transduction , biomarker , pathogenesis , biology , cell growth , medicine , bioinformatics , cancer , gene , immunology , genetics
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in clinical practice. The pathogenesis of HCC is still unclear. Currently, the clinical treatment of HCC is poorly targeted and the therapeutic effect is poor. MicroRNAs (miRNAs) are closely related to the occurrence of HCC, and they are mainly involved in the occurrence and development of HCC through binding to target genes or acting on related signaling pathways. In recent years, studies have shown that miRNA can be used as a potential biomarker for diagnosis and prognosis of HCC. In addition, studies have also shown that miRNA plays a tumor-suppressing or tumor-promoting role in the process of HCC by regulating the biological processes of tumor cell proliferation, migration, invasion and metastasis. In this paper, the recent studies on miRNA signaling pathways related to the occurrence and development of HCC were reviewed, with a view to providing ideas for the clinical diagnosis and treatment of HCC.