Effect of Recombinant Human Lactoferrin on Allergic Rhinitis in Mice Nasal Drip and Its Mechanism | Zendy

WANG Xiao-li | Zendy

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Effect of Recombinant Human Lactoferrin on Allergic Rhinitis in Mice Nasal Drip and Its Mechanism

Author(s) -

WANG Xiao-li

Publication year - 1970

Publication title -

journal of clinical and nursing research

Language(s) - English

Resource type - Journals

eISSN - 2208-3693

pISSN - 2208-3685

DOI - 10.26689/jcnr.v1i1.95

Subject(s) - lactoferrin , ovalbumin , mucous membrane of nose , nasal cavity , immunology , recombinant dna , allergy , infiltration (hvac) , medicine , chemistry , immune system , gene , biochemistry , physics , surgery , thermodynamics

Objective: To study the effect of recombinant human lactoferrin on allergic rhinitis in mice nasal drip and explore its possible molecular mechanism. Methods: The animalÂ model of allergic rhinitis in BALB / c mice was established byÂ ovalbumin. The eosinophils, goblet cells and mast cell infiltration of nasal mucosa were analyzed by hematoxylin-eosin,happening. The transcription factors and cytokines and expression levels of lactoferrin gene and protein of T lymphocyteÂ subsets in nasal cavity were detected by fluorescence quantitative RT-PCR and enzyme-linked immunosorbent assay. Spearman was used to analyzing the relationship between lactoferrinÂ expression levels and eosinophils in the nasal cavity.Â

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