Open AccessValues of blood copeptin level as a marker of unfavorable forecast in subarachnoid haemorrhage of the brain of atraumatic origin
Author(s) -
K. Yu. Polkovnikova
Publication year - 2020
Publication title -
endovaskulârna neĭrorentgenohìrurgìâ
Language(s) - English
Resource type - Journals
eISSN - 2663-6964
pISSN - 2304-9359
DOI - 10.26683/2304-9359-2019-4(30)-31-37
Subject(s) - copeptin , medicine , subarachnoid hemorrhage , prospective cohort study , subarachnoid haemorrhage , cardiology , anesthesia , surgery , aneurysm , vasopressin
Objective – to evaluate of diagnostic informativeness of сopeptin serum values in determining the risk of complications in patients with subarachnoid hemorrhage.Materials and methods. A prospective cohort study of 82 patients (40 men and 42 women) with spontaneous (non-traumatic) subarachnoid hemorrhage (SAH) from the age of 23 to 72 years (average age – (49,6 ±1,3) year) was conducted.Results. Complications were recorded in 31 (74.20 %) patients with a serum level of copeptin ≥ 0.605 ng/ml on the third day of the SAH, which was in 9.49 times higher (95 % CI 3.60–24.80, р ˂0.0001) than in patients with a serum level of copeptin < 0.605 ng/ml. When determining the cumulative risk of developing complications of SAH, the values of positive and negative predictive values of serum levels of copeptin on third day of SAH were 74.19 % and 92.20 % respectively, the accuracy of prediction (the sum of correctly classified observations) was 85.39 %.Conclusions. ROC-analysis suggests that the serum level of copeptin on third day of SAH ≥ 0.605 ng/ml is characterized by an optimal ratio of sensitivity and specificity in assessing the cumulative risk of developing such SAH complications as secondary ischemia combined with cerebral angiospasm.