Open AccessAntibacterial and antibiofilm activity of Begonia multangula Blume. leaf extract against Candida albicans
Author(s) -
Hasyrul Hamzah,
Khalish Arsy Al Khairy Siregar,
Y. Suffiana,
I. Yudhawan,
Ari Nurwijayanto
Publication year - 2022
Publication title -
food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.218
H-Index - 7
ISSN - 2550-2166
DOI - 10.26656/fr.2017.6(1).560
Subject(s) - candida albicans , biofilm , corpus albicans , fungus , microbiology and biotechnology , biology , begonia , antibacterial activity , pathogenic fungus , bacteria , botany , genetics
Candida albicans is a fungus that is included in the normal microbiota of humans. Ingeneral, C. albicans remains a lifelong commensal microorganism. This fungus has ahazardous impact. C. albicans can cause infection and is fatal. The spread of this fungus isone of the factors caused by antibiotic resistance, which causes C. albicans to be resistantand form strong colonies (biofilms) to survive. Natural ingredients for treatment is analternative that is often used by the community because their use is effortless andpractical. One of the plants is the leaves of Begonia multangula Blume. This plant isknown to have potent antifungal activity, but its antibiofilm activity against C. albicanshas not yet been reported in-depth about its antibiofilm. The discovery of new antibiofilmagainst C. albicans biofilms is a way to prevent the effects of infections caused by thesebiofilms. This research is a form of dedication to the effectiveness of Begonia multangulaBlume leaf extract in inhibiting and eradicating C. albicans biofilm formation. Planktonictesting, inhibition, and biofilm eradication activity were carried out using the microtiterbroth method. Antibiofilm activity of begonia leaves on C. albicans was measured bycalculating the minimum concentration of biofilm inhibitor (MBIC50). Data were analyzedusing the Statistical Package for the Social Sciences (SPSS) with a 95% confidence level.The begonia leaves showed inhibitory activity against the tested C. albicans biofilmformation. Begonia multangula Blume leaf extract 1% gave C. albicans antibacterialactivity of 75±0.01% and mid-phase antibiofilm activity of 65.21±0.01% and maturationphase of 50.11±0.01. The results also provided evidence that the ethanolic extract of C.albicans can degrade (eradication) the formation of C. albicans biofilms. Therefore, theethanol extract of begonia leaves can be developed as a new antibiofilm agent against C.albicans.