Open AccessAnti-gout potential of selected edible flowers
Author(s) -
Norsyamira Rosli,
Muhamad Fahmi Abu Bakar,
Fazleen Izzany Abu Bakar,
SheyLi Lim
Publication year - 2022
Publication title -
food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.218
H-Index - 7
ISSN - 2550-2166
DOI - 10.26656/fr.2017.6(1).156
Subject(s) - xanthine oxidase , hibiscus sabdariffa , chemistry , anthocyanin , flavonoid , allopurinol , food science , traditional medicine , botany , horticulture , biochemistry , biology , enzyme , antioxidant , medicine , pathology
Gout is a form of inflammatory arthritis triggered by the interaction between monosodiumurate crystals and tissues during the purine metabolism by xanthine oxidase. This studyaimed to determine the xanthine oxidase inhibitory activity, total phenolic content, totalflavonoid content and total anthocyanin content of 10 selected edible flowers, namelyRosa sp., Malus sp., Lavandula sp., Lilium sp., Hibiscus sabdariffa L., Chrysanthemumsp., Matricaria sp., Gomphrena sp., Myosotis sp. and Jasminum sp. extracted using hotwater infusion method. Phytochemical contents and the anti-gout activity of the flowerextracts using the xanthine oxidase inhibition assay were determinedspectrophotometrically. The results revealed that three aqueous flower extracts (Rosa sp.,Hibiscus sabdariffa L. and Malus sp.) exhibited potent xanthine oxidase inhibitory activity(IC50 values, 0.10±0.15 µg/mL, 0.12±0.11 µg/mL and 2.59±3.8 µg/mL, respectively),which were comparable to the positive control, allopurinol (IC50 value, 4.9±0.00 µg/mL).The highest phenolic and flavonoid contents were found in Lavandula sp. (4.39±0.13 mgGAE/g and 63.46±1.07 mg RE/g) while Rosa sp. showed the highest content ofanthocyanin (70.14±4.82 mg c-3-gE/g). Positive correlations were observed between thephytochemicals and xanthine oxidase inhibitory activity of the flower extracts. Hence, thisstudy suggests that Rosa sp., Hibiscus sabdariffa L. and Malus sp. possess anti-goutpotential, which is associated with the presence of possible anti-gout phytochemicals. Theisolation of the bioactive compounds that exhibit significant anti-gout activity among theselected flowers is recommended for future research.