Open AccessWound healing potential of palm oil tocotrienols rich fraction
Author(s) -
T.M. Ting,
Jaqueline King,
Kok Leong. Ho,
Harrison Lik Nang Lau
Publication year - 2021
Publication title -
food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.218
H-Index - 7
ISSN - 2550-2166
DOI - 10.26656/fr.2017.5(4).058
Subject(s) - metformin , wound healing , medicine , lipid peroxidation , diabetes mellitus , potency , pharmacology , surgery , endocrinology , chemistry , oxidative stress , in vitro , biochemistry
Diabetic patients often experience problems with their immune system activation andresult in delayed wound healing. Slow and incomplete wound healing increases the risk ofcomplications caused by infected wounds. Metformin has been used as a standard drug fordiabetes treatment and it accelerates wound healing. However, intake of metformin maycause gastrointestinal symptoms including diarrhoea, nausea and abdominal discomfort.Therefore, a safe alternative to metforminis is required. While many research programsfocus on alpha-tocopherol, in this paper the potency of tocotrienols in wound and diabetesmanagement was investigated. Tocotrienol rich fraction (TRF) was tested for its ability tostabilize blood glucose, reduce lipid peroxidation, promote platelet-derived growth factorBB and wound closure. In this study, the rodent model was used to investigate the effectsof TRP in wound healing proficiency. The results showed that TRF was comparable tometformin in stabilizing blood glucose, promoting PDGF-BB in the blood during theinitial wound healing stage and produced clean wound closure. Interestingly, the findingsof this study showed TRF had higher potency than metformin in reducing lipidperoxidation that could delay wound healing. Hence, TRF could be a good alternative tometformin in wound and diabetes management