Open AccessAntioxidant and anti-inflammatory dietary supplements in the treatment of osteoarthritis: a scoping review
Author(s) -
Ying Qian Ong,
H. Sakinah,
Mohd Razif Shahril,
S Norshazila
Publication year - 2019
Publication title -
food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.218
H-Index - 7
ISSN - 2550-2166
DOI - 10.26656/fr.2017.4(2).189
Subject(s) - medicine , placebo , nutritional supplementation , osteoarthritis , randomized controlled trial , traditional medicine , phytotherapy , oxidative stress , dietary supplement , physical therapy , alternative medicine , food science , pathology , chemistry
The increasing number of evidence has reported inflammation and oxidative stress as keymediators of osteoarthritis (OA) joint pathology. Therefore, the usage of dietarysupplements targeting inflammation and oxidative stress in OA may emerge as arewarding therapeutic strategy. This study aimed to explore the efficacy of antioxidant andanti-inflammatory dietary supplements used to manage OA. A methodological frameworkproposed by Arksey and O’Malley was used to conduct this scoping review. An electronicdatabase search of English academic articles was conducted using PubMed, MEDLINEand ScienceDirect from 2000 to 2018. Randomized controlled trials (RCTs) of OA withparallel groups by comparing dietary supplements with placebo consumption were eligiblefor inclusion. Out of 69,150 studies identified, a total of 41 studies were included, with 25antioxidant or anti-inflammatory dietary supplements identified. There were 3325respondents (1740 in the treatment group and 1585 in the placebo group), all aged ≥ 25years old and comprised of 69.6% and 30.4% female and male respondents, respectively.The majority of the studies recruited participants with knee OA (n = 33) with a follow-upduration of 3 to 32 weeks. Overall, most of the dietary supplements (n =17) demonstrateda beneficial effect on the clinical signs and symptoms, such as Boswellia serrata extract(BSE), Pycnogenol and L-carnitine. In contrast, Aquamin supplementation did not exertpositive impacts on OA management, while inconsistent findings were observed in greenlipped mussel (GLM) extract, vitamin E, methylsulfonylmethane (MSM), licoriceflavonoid oil (LFO), ginger, willow bark extract and rose hip supplementation. Insummary, the role of anti-inflammatory and antioxidant dietary supplements cannot beignored as they can offer alleviated pain and symptom relief.