Сombine therapy of patients with acne vulgaris comorbidity with functional disorder of hepatobiliary system and demodecosis

. One of the common chronic dermatoses that have a direct impact on the quality of life ofpatients is acne. The occurrence of psycho-emotional disorders due to the location of elements in the open areasof the body. Given the high prevalence of acne in puberty (up to 85 % of adolescents have episodes of acne of varying severity), there is a need to find new algorithms for acne treatment to prevent the progression of socialmaladaptation and depressive states.Materials and methods. The study included 140 patients who were divided into 3 groups dependingon the presence of comorbid pathology and treatment methods: group 1 — patients with acne who wereunderwent standard treatment for 60 days, group 2 — patients with acne in comorbidity with demodecosis,group 3 — patients with acne in comorbidity with demodecosis and functional disorders of the digestive system,who were additionally treated with a laser therapy. Treatment efficacy was evaluated using the GAGS scale andthe DLQI questionnaire on days 14, 28 and 60 of therapy.Results. Evaluation of the results on day 60 shows a decrease in the manifestations of inflammation by 50 %in groups 2 and 3, and by 29 % in the standard therapy group. Improving of the quality of life in groups 2 and 3was by 70 %, while in the group 1 — by 35 %. The following correlations were established: r = + 0.9 — between theseverity of VC manifestations and the presence of comorbid pathology, r = + 0.71 — between the severity of VCand the assessment of quality of life, r = + 0.69 — between the presence of acne comorbidity with demodecosisand FDGBS and the effect on quality of life (p < 0.005).Conclusions. Optimization of the treatment algorithm for acne patients in comorbidity with demodecosisand functional disorders of the hepatobiliary system is achieved by the use of combined treatment using lasertherapy, which significantly improves the quality of life of patients.