Open AccessThe antibacterial effect and lipid peroxidation index as an efficiency criterion of photodynamic therapy application in rats with infected radiation injuries
Publication year - 2018
Publication title -
fotobìologìâ ta fotomedicina
Language(s) - English
Resource type - Journals
eISSN - 2523-4617
pISSN - 2076-0612
DOI - 10.26565/2076-0612-2018-25-05
Subject(s) - photodynamic therapy , malondialdehyde , pseudomonas aeruginosa , methylene blue , lipid peroxidation , myeloperoxidase , medicine , pathogenic bacteria , inflammation , necrosis , pharmacology , microbiology and biotechnology , bacteria , chemistry , immunology , oxidative stress , biology , biochemistry , photocatalysis , organic chemistry , genetics , catalysis
In the experiment with rats we studied the impact of photodynamic therapy with methylene blue on elimination of pathogenic bacteria in radiation ulcers infected by Pseudomonas aeruginosa. We showed the system impact of local photodynamic therapy on pro- and antioxidant system recovery. The spike of increase of blood serum malondialdehyde level in radiation ulcers dynamic development may be used as a criterion of process severity (necrosis, inflammation). The expediency is proved of photodynamic therapy effectiveness for decontamination of bacterial flora on the wound surface of the radiation ulcer and self antioxidant protection system recovery.