Open AccessAspirin as a Chemopreventive Agent for Cancer: a New Hope?
Author(s) -
Isnatin Miladiyah
Publication year - 2016
Publication title -
sains medika/sains medika : jurnal kedokteran dan kesehatan
Language(s) - English
Resource type - Journals
eISSN - 2339-093X
pISSN - 2085-1545
DOI - 10.26532/sainsmed.v6i2.605
Subject(s) - medicine , aspirin , cancer , cancer prevention , inflammation , immunology , prostate cancer , oncology , cancer research
inflammation has been shown to play a major role in the pathogenesis of cancer. Inflammatory process activates the immune system through pro-inflammatory mediators and subsequent triggers transformation into malignant cells. Some tumors or cancers has been associated with chronic infections, such as hepatitis B and C viruses (hepatocellular carcinoma), human papilloma virus (cervical cancer), Helicobacter pylori (gastric cancer and lymphoma), and prostatitis (prostate cancer). A considerable study have investigated the benefits of aspirin for the prevention and treatment of cancer or tumors. Objectives: This paper aims to describe the relationship between inflammation and cancer incidence, so that use of aspirin as an anti-inflammatory agent is a rational choice in the treatment and prevention of cancer. Conclusion: Aspirin potential for chemoprevention of various types of cancer. Considering the high risk of side effects of aspirin, aspirin is not intended as a routine therapy to prevent the occurrence of cancer.