Open AccessMembrane stabilization effect and histological changes in the heart in experimental myocardial rats with Zanthoxulym armatum fruit
Author(s) -
Malathi Mangalanathan,
Tamiloli Devendhiran,
Saraswathi Uthamaramasamy,
Keerthika Kumarasamy,
K Mohanraj,
Kannagi Devendhiran,
T. Suganya,
Mei Lin
Publication year - 2019
Publication title -
south asian journal of engineering and technology
Language(s) - English
Resource type - Journals
ISSN - 2454-9614
DOI - 10.26524/sajet190805
Subject(s) - atpase , membrane , adenosine , chemistry , medicine , sodium , potassium , myocyte , enzyme , endocrinology , biology , biochemistry , organic chemistry
Membrane bound adenosine triphosphatases (ATPases) shed a massive function into the contraction and relaxation of the heart muscle via keeping the normal ion levels within the myocyte. The current study aims to assess the potency of Zanthoxylum armatum (Z. armatum) fruit on membrane bound ATPases and ions in Isoproterenol (ISO) induced myocardial infracted rats. The hydroethanolic extract of Z. armatum fruit was administered at a dose of 200 and 400mg/kg body weight for 30 days to male Wistar albino rats. On 28th and 29th day, ISO (8.5mg/100g body weight) used to be administered to induce myocardial infarction (MI). ISO treated rats confirmed a significant increase in the levels of tissue sodium (Na+) and calcium (Ca2+) ions and membrane bound Ca2+ ATPase then Mg2+ ATPase activity. A significant decrease in tissue potassium (K+), Na +/K+ ATPase was observed which indicates membrane destabilization. Pretreatment with hydroethanolic extract of Z. armatum fruit to ISO induced rats significantly (p<0.05) prevented the altered membrane bound enzymes to near normal status. The findings of the present study indicate the protective effect of Z. armatum fruit on altered ion pumps and destabilization on the cardiac membrane into ISO induced MI rats which might also be due to the presence of phytoconstituents.