Open AccessVav1 and mutant K-Ras synergize in the early development of pancreatic ductal adenocarcinoma in mice
Author(s) -
Yaser Salaymeh,
Marganit Farago,
Shulamit Sebban,
Batel Shalom,
Eli Pikarsky,
Shulamit Katzav
Publication year - 2020
Publication title -
life science alliance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.57
H-Index - 14
ISSN - 2575-1077
DOI - 10.26508/lsa.202000661
Subject(s) - cancer research , pancreas , rac1 , medicine , signal transduction , biology , biochemistry
Wild-type Vav1 and mutant K-Ras synergistically accelerate pancreatic acinar-to-ductal metaplasia (ADM), thus leading to pancreatic ductal adenocarcinoma (PDAC), depending on Vav1’s activity as a GEF for Rac1.