Open AccessOxidative Stress in Multiple Sclerosis Disease (Review Article)
Author(s) -
Sura Mohammed Kadhim,
AUTHOR_ID,
Sura Mohsin Abbood,
Y M Taay,
Mustafa Taha Mohammed
Publication year - 2021
Publication title -
maǧallaẗ diyālá al-ṭibbiyyaẗ/maǧallaẗ diyālá al-ṭibbiyyaẗ
Language(s) - English
Resource type - Journals
eISSN - 2617-8982
pISSN - 2219-9764
DOI - 10.26505/djm.21026040523
Subject(s) - oxidative stress , multiple sclerosis , reactive oxygen species , disease , oxidative phosphorylation , oxidative damage , antioxidant , medicine , myelin , biology , chemistry , central nervous system , immunology , biochemistry
Background: Multiple sclerosis (MS) is an inflammatory disease of the central nervous system, in which the myelin sheaths got injured. The prevalence of MS is on grow, as well as, it affects the young ages. Females are most common to have MS compared to males. Oxidative stress is the situation of imbalance between oxidants (free radicals and reactive oxygen species (ROS)) and antioxidants in a living system, in which either the oxidants are elevated or antioxidants are reduced, or sometimes both. ROS and oxidative stress have been implicated in the progression of many degenerative diseases, which is important in cracking the unrevealed mysteries of MS. In this review article, some of the proposed mechanisms that link oxidative stress with MS disease would be described. Keywords: Oxidative stress, ROS, multiple sclerosis, antioxidants