Open AccessSTUDY ON CHEMICAL CONSTITUENTS AND CYTOTOXICITY OF ASPIDISTRA LETREAE
Author(s) -
Đức Việt Hồ
Publication year - 2020
Publication title -
tạp chí khoa học đại học huế: khoa học tự nhiên/tạp chí khoa học đại học huế: khoa học tự nhiên (online)
Language(s) - English
Resource type - Journals
eISSN - 2615-9678
pISSN - 1859-1388
DOI - 10.26459/hueuni-jns.v129i2a.5656
Subject(s) - cytotoxicity , chemistry , stereochemistry , in vitro , biochemistry
A phytochemical investigation of whole Aspidistra letreae plants led to the isolation of 2 H -chromen-2-one ( 1 ), α -tocopherol ( 2 ), ( E )-phytol ( 3 ), asparenydiol ( 4 ) and (25 S )-spirost-1 β ,3 α ,5 β -triol ( 5 ). Their structures were determined on the basis of NMR spectral evidences and in comparison with the reported data. Of these, asparenydiol ( 4 ) was isolated from the genus Aspidistra for the first time. This is also the first report on the separation and structural determination of (25 S )-spirost-1 β ,3 α ,5 β -triol ( 5 ) as a pure compound. The methanol extract exhibited a moderate cytotoxicity against the LU-1, HeLa, MDA-MB-231, Hep-G2, and MKN-7 human cancer cell lines with IC 50 values ranging from 52.58 ± 3.65 to 64.78 ± 4.89 μg/mL.