Open AccessSerum Cotinine Level as a Tobacco Exposure Related Biomarker in Oral Cavity Malignancy
Author(s) -
Anand Guddur,
Aayush Shah,
Amol D Langade,
Shreesh A Kolekar,
Lahoti Jeevan,
Nikam Yogesh Prahlad
Publication year - 2020
Publication title -
international journal of research in pharmaceutical sciences
Language(s) - English
Resource type - Journals
ISSN - 0975-7538
DOI - 10.26452/ijrps.v11ispl4.4440
Subject(s) - medicine , chewing tobacco , cotinine , malignancy , cancer , biomarker , basal cell , gastroenterology , incidence (geometry) , risk factor , tobacco smoke , physiology , nicotine , environmental health , biochemistry , chemistry , physics , optics
Oral cancer has posed a challenge to us with its incidence as high as around 20% of total body cancers aim of the study was to quantify serum cotinine level as tobacco exposure-related biomarker in controls, chronic tobacco chewers (High risk for oral cavity malignancy) and oral cavity cancer patients. This was a hospital-based case-control study of 24 months duration in controls, chronic tobacco chewers and oral cancer patients. A total of 150 subjects had enrolled after meeting the inclusion & exclusion criteria. The commonest age group of oral cavity malignancy was 41 to 50 years. Males were found to be more affected than females. Tobacco chewing was the most common habits in a male patient and mishri application in female patients. In this study, 90% of patients had a history of tobacco consumption for the last ten years or more. Frequency of tobacco chewing was more in chronic tobacco chewers (30% in more than ten times a day) compared to oral cavity malignancy group (16% in more than ten times a day). The majority (more than 50%) of patients had tumour arising from the buccal mucosa, and histopathological studies revealed that 48% of patients had well-differentiated squamous cell carcinoma. Serum cotinine level in non-tobacco exposure group is less than 1 ng/mL. Conclusion- Tobacco chewing habit is a high-risk factor for oral cancer. Chronic tobacco chewers can be included in the high-risk group for oral cavity cancer. Serum cotinine level can be used as a tumour marker for oral cancer patients.