Open AccessA Perspective View on Formulation and Optimization of Curcumin Loaded Phycocyanin Nanosponges
Author(s) -
Manjuladevi Kasirajan,
Ramaiyan Velmurugan
Publication year - 2020
Publication title -
international journal of research in pharmaceutical sciences
Language(s) - English
Resource type - Journals
ISSN - 0975-7538
DOI - 10.26452/ijrps.v11i4.4874
Subject(s) - curcumin , sonication , bioavailability , zeta potential , pulmonary surfactant , particle size , chemistry , chemical engineering , materials science , nanotechnology , chromatography , pharmacology , biochemistry , nanoparticle , medicine , engineering
Curcumin have a wide range of pharmacological activity and used in various disorders. Due to its poor bioavailability and fast metabolism peripherally, it is a major obstacle for researchers. Recent research on nanotechnology paved the way to overcome above concern and good results were obtained in formulation of curcumin using nanotechnology. The main objective of the study is to optimize, formulate & develop the curcumin loaded phycocyanin nanosponges and determine the variation in responses with respect to factors. The nanosponges were prepared using solvent evaporation technique and the final curcumin loaded Phycocyanin nanosponges (Cur-PC-NS) formulation is optimized and characterized. The formulation factors like drug polymer ratio, Aqueous/ Organic (A/O) phase ratio, concentrations of surfactant, Sonication & stirring time were considered as function excipient have shown different response values in aspects of Particle Size (PS), Zeta Potential (ZP), % of entrapment efficiency (EE%) & Loading capacity (LC%). In our findings F8 formulated nanosponges got 121.9nm particle size; -25.1mV zeta potential; 84.98% of Entrapment efficiency & 52.92% of loading capacity. Thus exhibited change in A/O phase ratio, surfactant concentration & Sonication time are 5:1, 0.5%, 1 hour respectively which have great impact on PS, EE% & LC%. We conclude that factor and its positive impact on response have to be taken in concern and utilized; we can develop better sustain release curcumin loaded phycocyanin nanosponges