Open AccessResponse of biogenic zinc oxide nanoparticles against periimplantitis triggering non periodontal pathogen
Author(s) -
Shivkanya Fuloria,
Chiam Sin Ru,
Neeraj Paliwal,
Kalyana Sundram,
Kathiresan V. Sathasivam,
Sameep Singh,
K. C. Gupta,
Neeraj Kumar Fuloria
Publication year - 2020
Publication title -
international journal of research in pharmaceutical sciences
Language(s) - English
Resource type - Journals
ISSN - 0975-7538
DOI - 10.26452/ijrps.v11i3.2573
Subject(s) - zinc , absorbance , nuclear chemistry , fourier transform infrared spectroscopy , aqueous solution , chemistry , nanoparticle , materials science , chromatography , nanotechnology , chemical engineering , organic chemistry , engineering
Biogenic zinc oxide nanoparticles (BZnONPs) as a nano medicine attain high importance in the treatment of Peri Implantitis (PI). Present study was aimed to biosynthesize, optimize, characterize and evaluate the response of BZnONPs against PI triggering non periodontal pathogen. The BZnONPs synthesis, characterization, optimization and stability were based on UV-Visible, FTIR, XRD, FESEM, and EDX data. The BZnONPs were tested against S. aureus. Treatment of zinc acetate with Dimocarpus longan leaves extract resulted in formation of BZnONPs, which exhibited the absorbance signal between 350- 359 nm. Optimization study established 0.05 M zinc acetate, 6 ml of DLL aqueous extract, pH 12, and 2 h stirring time as parametric requirements for BZnONPs synthesis. Stability study of BZnONPs exhibited absorbance at 340 nm. The BZnONPs were characterized based on broad and shifted FT-IR bands, XRD signals (at 2θ values of 31.70◦ , 34.33◦ , 36.19◦ , 47.45◦ , 56.52◦ , 62.78◦ , 67.88◦ and 72.45◦ ), size range from 42.07-61.33 nm in FESEM, and elemental zinc 74.22 % in EDX spectrum. The BZnONPs exhibited high inhibitory response towards S. aureus. Present study establish that BZnONPs synthesis using Dimocarpus longan leaves aqueous extract is a facile method and reports that BZnONPs could be potential remedy for PI.