Open AccessPhenytoin induced Steven Johnson syndrome
Author(s) -
Naga Subrahmanyam S,
G Nagaraju,
Tagoore Vijaya Lakshmi D
Publication year - 2020
Publication title -
international journal of research in pharmaceutical sciences
Language(s) - English
Resource type - Journals
ISSN - 0975-7538
DOI - 10.26452/ijrps.v11i1.1803
Subject(s) - phenytoin , adverse effect , anticonvulsant , medicine , pharmacist , pharmacology , adverse drug reaction , anesthesia , epilepsy , drug , psychiatry , pharmacy , family medicine
Phenytoin is an anticonvulsant and Hydantoin, it is mainly used in the management o Seizures, and it stabilizes the neuronal membranes and decreases seizure activity by increasing efflux or reducing the influx of sodium ions across cell membranes in the motor cortex during the generation of nerve impulses. It is available in the market in the form of oral and intravenous forms, a loading dose of Phenytoin for the management of seizures is 10-20 mg, divided into 2-3 doses. Stevens-Johnson syndrome is a rare and serious adverse effect of the skin along with the membranes of the mucous. It is caused by specific Drugs or Viral Infections. We have performed causality assessment by using the WHO and NARANJO'S ADR rating scale. It will seem, it is a Probable ADR, and severity assessed it confers a Type-A ADR, and it should be in Probably Preventable. So being a Reliable Clinical Pharmacist, we recommend to all health care professionals be aware of adverse drug reactions, and Desirable vigilance is necessitated toward safe and effective management for specific patients, strictly observe the patients in sequence anticipate Dangerous Adverse events.