Open AccessStarch/hyaluronic acid/sorbitol composite films as potential wound dressing materials that protect against P. Aeruginosa
Author(s) -
Ramli Muhammad Zaki,
Kalavathy Ramasamy,
Rakesh K. Mishra,
Abu Bakar Abdul Majeed,
SeongHoon Lim
Publication year - 2019
Publication title -
international journal of research in pharmaceutical sciences
Language(s) - English
Resource type - Journals
ISSN - 0975-7538
DOI - 10.26452/ijrps.v10ispl1.1705
Subject(s) - hyaluronic acid , pseudomonas aeruginosa , microbiology and biotechnology , ciprofloxacin , sorbitol , staphylococcus aureus , chloramphenicol , chemistry , composite number , materials science , antibiotics , medicine , bacteria , biology , food science , composite material , genetics , anatomy
Bacterial infection is one of the key challenges to the wound healing process. Ideal wound dressing materials should, therefore, be able to inhibit bacterial infection. The present study evaluated the antibacterial properties of composite films for use as wound dressing materials. The composite films, which were made up of starch, sodium hyaluronic acid (SHA), and sorbitol, were prepared at varying concentrations of hyaluronic acid (25-100mg) by solvent casting method. The composite films were tested against gram-negative Escherichia coli, Pseudomonas aeruginosa, and Salmonella typhimurium as well as gram-positive Staphylococcus aureus for 24 hours by using the disc diffusion assay. Chloramphenicol and ciprofloxacin were included as positive controls. Amongst the tested pathogens, composite films with SHA > 25mg inhibited only P. aeruginosa. It is noteworthy that the antibacterial effect of composite films with SHA > 50mg were comparable to those of chloramphenicol and ciprofloxacin. The present findings implied the possible incorporation of starch/ hyaluronic acid/ sorbitol composite films as part of wound dressing for protection against infection caused by P. aeruginosa.