Open AccessDevelopment and radiographical evaluation of floating tablets with combination of Amoxicillin Trihydrate and Ranitidine Hydrochloride
Author(s) -
P Srikanth,
S Hemalatha,
S. Satyanarayana
Publication year - 2019
Publication title -
international journal of research in pharmaceutical sciences
Language(s) - English
Resource type - Journals
ISSN - 0975-7538
DOI - 10.26452/ijrps.v10i2.727
Subject(s) - ranitidine , ranitidine hydrochloride , antacid , amoxicillin , granulation , dosage form , medicine , chromatography , pharmacology , chemistry , materials science , gastroenterology , composite material , antibiotics , biochemistry
Stomach Specific Floating Tablets (SSFT) with a combination of Amoxicillin-Trihydrate (AT) and Ranitidine Hydrochloride (RH) were developed by using different grades of Hydroxypropylmethylcellulose (HPMCK) (i.e.HPMCK 100M, HPMCK4M and HPMCK15M), to treat patients with H. pylori-infected duodenal ulcer. Floating tablets were prepared by direct compression method, developed formulations were evaluated for different pre-compression and post-compression parameters like angle of repose, compressibility index, hardness, weight variation, floating lag time, content uniformity, and in-vitro drug release. In-Vitro release of two drugs (Amoxicillin-Trihydrate and Ranitidine hydrochloride) from the developed formulation was estimated by the Simultaneous Estimation method (Vierordt's Method). The optimized formulation was subjected to Radio graphical evaluation by incorporating the BaSO4, a radio-opaque substance by replacing a part of the drug from the optimized formulation of into the formulation and then it was administered to the healthy human volunteers to find out the in-vivo residence time. In-vivo X-ray studies were conducted both in fed condition, as well as fasted condition the optimized formulation showed a gastric residence time of more in fed state than that of fasting state. From these studies it was clearly observed that the floating tablets should be given to patients after a standard food and with frequent intake of water.