Open AccessBiological evaluation of synthesised thiazolidinedione derivatives for anti-diabetic activity on STZ caused diabetes in rats
Author(s) -
B.R. Geetha,
G Swarnalatha,
G. V. Subbareddy
Publication year - 2019
Publication title -
international journal of research in pharmaceutical sciences
Language(s) - English
Resource type - Journals
ISSN - 0975-7538
DOI - 10.26452/ijrps.v10i2.379
Subject(s) - thiazolidinedione , pioglitazone , diabetes mellitus , medicine , pharmacology , drug , chemistry , receptor , biological activity , endocrinology , biochemistry , in vitro , type 2 diabetes
Diabetes Mellitus is the most common disease that poses a challenge to human health due to its secondary complications and resistance. Therefore, an attempt was made to synthesize novel compounds from thiazolidinedione moiety to treat the disease effectively and target diabetic complications. The synthesized compounds were tested for their physical parameters and characterised using NMR and IR spectra. They were also evaluated for STZ induced anti-diabetic activity in albino rats. The Compounds P5, II A8 and A9 were found effective in comparison with a standard drug, Pioglitazone. The other compounds were also effective but a reduction in activity is seen might be due to the inefficient binding to the PPAR receptors.