Open AccessIdentification of anticancer activity of phytoconstituents from mangrove
Author(s) -
Sheela Devi A,
Jeena Joseph,
. Bhuvaneshwari
Publication year - 2019
Publication title -
international journal of research in pharmaceutical sciences
Language(s) - English
Resource type - Journals
ISSN - 0975-7538
DOI - 10.26452/ijrps.v10i2.254
Subject(s) - hela , traditional medicine , mangrove , tannin , medicinal plants , saponin , biology , phytomedicine , cancer cell lines , chemistry , cancer , cancer cell , botany , medicine , cell , biochemistry , ecology , alternative medicine , genetics , pathology
Medicinal plants from the marine ecosystem are a rich source of medicinal plants having a potential for miracle drugs. It is clear from the observation that the local inhabitants of Pichavaram mangrove forest have excellent knowledge about the phytomedicine. Thus they have developed their traditional system of utilizing these mangroves for medicinal purposes. Cancer is the name given to a collection of related and multistep disease. In all types of cancer, a few of the body's cells begin to divide without stopping and spread into the surrounding. It is developed by environmental, physical, chemical, metabolic and genetic factors. In this study, methanol was used to prepare an extract from A. marina leaves and screened for anticancer activity. The phytoconstituents like alkaloids, flavonoids, saponin and tannin present in the extract were quantified, and anticancer activity of the same was identified. Further, the apoptotic cell death effect of methanol extract on the Hela cell line was determined. The flavonoids of A. marina showed higher anti-cancer activity on Hela cells followed by tannin, alkaloids and saponin. The result of the apoptotic cell death effect of A. marina may provide an effective therapeutic strategy against cervical cancer. Finally, it is concluded that the extract of A. marina exhibited anticancer activity.