Open AccessFormulation and Evaluation of Prolonged-Release Tablets Containing Solid Dispersions of Rosuvastatin Calcium
Author(s) -
Gnana Prakash
Publication year - 2021
Publication title -
future journal of pharmaceuticals and health sciences
Language(s) - English
Resource type - Journals
ISSN - 2583-116X
DOI - 10.26452/fjphs.v1i4.180
Subject(s) - bioavailability , rosuvastatin calcium , dissolution , rosuvastatin , dispersion (optics) , solubility , immediate release , chromatography , chemistry , pharmacology , peg ratio , calcium , materials science , peg 400 , chemical engineering , medicine , organic chemistry , engineering , physics , polyethylene glycol , business , finance , optics
Pharmaceutical Industry is striving hard to improve the dissolution of drugs with limited water solubility. One of the approaches to improve the dissolution rate of poorly soluble drugs is solid dispersion. Hence in the present research, an attempt was made to improve the bioavailability of Rosuvastatin by formulating it as a solid dispersion. The release of Rosuvastatin calcium solid dispersion was prolonged using HPMC. Eudragit L-100 and PEG-6000 were used as carriers. Nine formulations of prolonged-release Rosuvastatin calcium (RS-SD 1 to RS-SD 9) were prepared and evaluated for pre and post formulation studies. Among all the formulations RS SD-3 showed an optimum release profile with 97.5±3.89 % indicating it to be the best formulation in the present research.