Open AccessRP-HPLC Method Designed for Determining Charantin in its Capsule Dosage Form
Author(s) -
Gnana Prakash
Publication year - 2021
Publication title -
future journal of pharmaceuticals and health sciences
Language(s) - English
Resource type - Journals
ISSN - 2583-116X
DOI - 10.26452/fjphs.v1i3.219
Subject(s) - capsule , high performance liquid chromatography , dosage form , bioequivalence , chromatography , insulin , chemistry , raw material , mathematics , pharmacology , bioavailability , medicine , microbiology and biotechnology , biology , botany , organic chemistry
Charantin, a steroidal saponin found in the plant Momordica charantia and functions like insulin. It is combined with natural insulin, increasing insulin release and inhibiting gluconeogenesis. Charantin improves blood glucose levels by enhancing glucose absorption and glycogen synthesis in the liver, muscles, and fat cells, according to a large body of research. The great majority of the time, it is taken in the form of a capsule. Because of the increased availability of these newly released formulations, a new way of calculating the amount of medications included in the formulations is now required. The current work's RP-HPLC technique is aimed to estimate Charantin as well as confirm that Charantin is being calculated. The proposed RP-HPLC technology for assessing Charantin in capsule dosage form was found to be precise, specific, accurate, quick, and cost-effective. Label Claims (also known as labelling claims) are representations of the actual product attributes as stated on the product label. The sample recoveries from all formulations were consistent with their respective Label Claims, and this method is suitable for routine analysis. It is suitable for normal laboratory analysis and may be used to control the quality of raw materials, formulations, dissolution tests, and bioequivalence studies for the same formulation.