Open AccessThe Subnuclear Distribution of 5-HT1A Receptors in the Human Nucleus of the Solitary Tract and Selected Structures of the Caudal Medulla
Author(s) -
Christopher F. Spurney,
Donald C. Ohuoha,
Angela M. Murray,
Joel E. Kleinman,
Thomas M. Hyde
Publication year - 2020
Publication title -
mcgill journal of medicine
Language(s) - English
Resource type - Journals
eISSN - 1715-8125
pISSN - 1201-026X
DOI - 10.26443/mjm.v3i2.547
Subject(s) - dorsal motor nucleus , solitary tract , nucleus , receptor , medulla , 5 ht4 receptor , medulla oblongata , dorsum , dorsal raphe nucleus , anatomy , agonist , neuroscience , 5 ht receptor , solitary nucleus , vagus nerve , biology , medicine , central nervous system , serotonin , stimulation , serotonergic
The distribution of 5-HT1A receptors in the subnuclei of the human caudal nucleus of solitary tract and adjacent structures in the dorsal vagal complex was studied using [3H]8-OH-DPAT, a highly selective 5-HT1A receptor agonist. The highest binding of the labeled ligand was found in the dorsal motor nucleus of the vagus, followed by the medial, intermediate, and subpostremal subnuclei of the nucleus of solitary tract. Previous animal studies suggest an important role for these structures in the regulation of visceral function, particularly for the gastrointestinal and cardiovascular systems. The results of this study suggest the possibility of an analogous role for 5-HT1A receptors in the regulation of these autonomic pathways in humans as well.