Open AccessHepatic decompensation associated with an interferon-free antiviral therapy in patients with HCV-cirrhosis
Author(s) -
S.N. Batskikh,
E.V. Vinnitskaya,
Yu.G. Sandler,
T.Yu. Кhaimenova
Publication year - 2018
Publication title -
terapevtičeskij arhiv
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.181
H-Index - 14
eISSN - 2309-5342
pISSN - 0040-3660
DOI - 10.26442/terarkh2018901167-73
Subject(s) - medicine , decompensation , cirrhosis , antiviral therapy , portal hypertension , gastroenterology , hepatitis c , chronic hepatitis , intensive care medicine , immunology , virus
Today, there is no complete clarity about the pathogenetic mechanisms of the hepatic decompensation in patients with HCV-cirrhosis during the course of direct-acting antiviral (DAAs) therapy. The current article describes several clinical observations of decompensation (with the development of liver failure and portal hypertension) in cirrhotic patients during the course of DAAs-therapy of hepatitis C. The authors present contemporary views and their own assumptions about the possible mechanisms of the hepatic decompensation associated with DAAs-therapy in patients with liver cirrhosis.