Angiotensin receptor blockers in nephroprotection at patients with diabetes mellitus: focus on losartan

Many large studies have provided strong evidence that there is an association of elevated BP with a risk for cardiovascular events (CVE),such as stroke, myocardial infarction and heart failure. But none of the studies has indicated that a drug is more effective than another onein reducing the risk for CVE and death. The article summarizes the available data on ramipril in hypertensive patients of high cardiovascularrisk. The results of studies demonstrate strong and long-lasting antihypertensive effect of losartan. Moreover, losartan treatmentdecreases cardiovascular events rate, damage of target organs, atherosclerosis progression and new cases of diabetes mellitus. Losartanshows both high efficacy and low adverse event rate.