Open AccessThe level of uric acid and its role at early stages of essential hypertension
Author(s) -
Е. В. Ощепкова,
Ощепкова Елена Владимировна,
В. В. Дмитриев,
В. В. Дмитриев,
O Polovitkina,
O Polovitkina,
В Н Титов,
В Н Титов
Publication year - 2009
Publication title -
sistemnye gipertenzii
Language(s) - English
Resource type - Journals
eISSN - 2542-2189
pISSN - 2075-082X
DOI - 10.26442/sg28854
Subject(s) - urine , uric acid , essential hypertension , medicine , blood pressure , creatinine , renal function , endocrinology , c reactive protein , gastroenterology , inflammation
Aim: correlation of uric acid (UA) level on serum blood and urine with indicators of not specific inflammation and clinicalcharacteristic in essential hypertension (EH) patients. Methods: 67 patients with EH (48 men) 30-65 years age (442) withstage 1 EH (n=37) and 2 (n=30) with moderate or high cardiovascular (CV) risk. The control group - 14 healthy peoples: (6men) 45,52,1 years age with normal blood pressure (BP). The normal level of С-reactive protein (CRP) is less 3 mg/l. Thenormal level of UA in blood is 202,3-416,5 mkmol/l, and in urine is 1,48-4,43 mmol/24 hour. The estimates of creatinineclearance by the Cockroft-Gault formula. Results: the patients with EH have bigger level CRP, UA in blood and urine thanhealthy peoples with normal BP. Higher levels UA in blood and urine have patients even with early stages EH and moderateCV risk. The bigger level of UA in blood has EH patients with obesity and dyslipidaemia. The level of UA in blood and urine ishigher at EH patients with hyperfiltration vs patients with normal creatinine clearance. Conclusion: the patients with earlystage of EH have higher level of UA in blood and urine than healthy peoples with normal BP. The level of UA in blood andurine is correlated with dyslipidaemia. Key words: essential hypertension, uric acid, non specific inflammation