Open AccessAssessing the impact of antihypertensive therapy on ambulatory blood pressure monitoring in patients with isolated systolic hypertension
Author(s) -
V. A. Aydarova,
Айдарова Виктория Анатольевна,
Z. T Astahova,
Астахова Замира Татарбековна,
Ф. У. Канукова,
Канукова Фариза Умарбековна,
M. M Besaeva,
Бесаева Мадина Михайловна
Publication year - 2014
Publication title -
cardiosomatika
Language(s) - English
Resource type - Journals
eISSN - 2658-5707
pISSN - 2221-7185
DOI - 10.26442/cs45038
Subject(s) - blood pressure , medicine , perindopril , indapamide , amlodipine , ambulatory blood pressure , cardiology , systolic hypertension , diastole , essential hypertension , ambulatory , diuretic
The study examined the effectiveness of drug correction of high numbers of blood pressure (BP) by means of modern groups of antihypertensive drugs, the effect of a fixed combination of perindopril and indapamide on circadian blood pressure monitoring, and a commitment to patients of antihypertensive therapy, based on the opened simple randomization three groupswere formed: 1st comprised of 21 patients with isolated systolic hypertension (ISAH) and 22 patients with systolic-diastolic hypertension (SDAH) - they all received monotherapy with calcium antagonists (amlodipine 10 mg/day); Group 2 - of 16 ISAH patients and 24 SDAH patients - who received monotherapy with perindopril (2 mg/day) and the third group - of 17 patients with ISAH and 14 patients with SDAH - who received combination therapy with the drug noliprel (Servier) with a fixed combination of perindopril (2 mg) and indapamide of 0,625 mg. Treatment efficacy was assessed primarily to reduce the absolute numbers of blood pressure, and taken into account as a reduction in systolic blood pressure (SBP) and diastolic blood pressure (DBP), uncontrolled drop of which, according to the literature, in elderly patients can have fatal consequences