Open AccessFeatures of anti-ischemic efficacy of trimetazidine MR, assigned in combination with metoprolol in patients with angina
Author(s) -
P. Yu. Bardybakhin,
Бардыбахин Павел Юрьевич,
Е. В. Бочкарева,
Бочкарева Елена Викторовна,
I. V Kim,
Ким Ирина Витальевна
Publication year - 2013
Publication title -
cardiosomatika
Language(s) - English
Resource type - Journals
eISSN - 2658-5707
pISSN - 2221-7185
DOI - 10.26442/cs44992
Subject(s) - trimetazidine , metoprolol , medicine , cardiology , angina , stable angina , ischemia , coronary heart disease , myocardial infarction
We studied the influence of trimetazidine MR on exercise tolerance and carbohydrate metabolism in 28 patients with stable effort angina, treated with metoprolol. The addition of trimetazidine MR to ongoing therapy with metoprolol substantially enhanced the antianginal and anti-ischemic efficacy of treatment. The most significant improvement was observed when the monotherapy with metoprolol wasn’t effective. In this subgroup of patients the threshold exercise duration increased by 77,1±18,1 s (p