Open AccessBiological drugs in the therapy of atopic dermatitis and bronchial asthma: focus on dupilumab
Author(s) -
Vera Reviákina,
V A Revyakina,
Н.А. Геппе,
Геппе Наталья Анатольевна,
А.Б. Малахов,
Малахов Александр Борисович,
О. В. Калюжин,
Калюжин Олег Витальевич,
Н. Г. Астафьева,
Астафьева Наталья Григорьевна,
Н.Г. Колосова,
Колосова Наталья Георгиевна,
Mariia A. Malakhova-Kapanadze,
Малахова-Капанадзе Мария Александровна
Publication year - 2021
Publication title -
pediatriâ. consilium medicum
Language(s) - English
Resource type - Journals
eISSN - 2658-6630
pISSN - 2658-6622
DOI - 10.26442/26586630.2021.2.201053
Subject(s) - dupilumab , atopic dermatitis , medicine , asthma , eosinophilic , immunology , dermatology , disease , pathology
Significant progress has been made over the past decade in the treatment of allergic diseases such as atopic dermatitis and bronchial asthma. Dupilumab, which targets interleukin IL-4 and IL-13, has become an innovative targeted therapy. Immunobiologic therapy with the interleukin inhibitor is indicated for patients with moderate to severe uncontrolled atopic dermatitis, moderate to severe eosinophilic phenotype of uncontrolled Bronchial asthma and patients with poorly controlled severe chronic polyposis rhinosinusitis. A clinical case and recent data on the use of dupilumab for the treatment of type 2 inflammatory disease and prospects for its use are discussed.