Open AccessAssessment of the effect of nebivolol and сarvedilol on the functional state of patients with diastolic chronic heart failure
Author(s) -
В. Г. Трегубов,
Трегубов Виталий Германович,
P. V. Khilkevich,
Хилькевич Павел Владимирович,
Iosif Z. Shubitidze,
Шубитидзе Иосиф Зурабович,
Anna V. Tregubova,
Трегубова Анна Витальевна
Publication year - 2021
Publication title -
cardiosomatika
Language(s) - English
Resource type - Journals
eISSN - 2658-5707
pISSN - 2221-7185
DOI - 10.26442/22217185.2020.4.200565
Subject(s) - nebivolol , medicine , carvedilol , heart failure , cardiology , ejection fraction , bisoprolol , diastole , diastolic heart failure , blood pressure
Aim. To determine the effect of combined therapy with nebivolol or carvedilol on the functional state of patients with diastolic chronic heart failure (CHF).
Material and methods. The study involved 68 patients with CHF and preserved left ventricular ejection fraction, who were randomized into two groups for treatment with bisoprolol or carvedilol. As part of the combination therapy was prescribed quinapril, and if indicated atorvastatin, acetylsalicylic acid in the intestinal soluble shell. Initially and after 24 weeks of therapy were carried out: quantitative assessment of regulatory-adaptive status (RAS), echocardioscopy, treadmill test, six-minute walking test, subjective assessment of quality of life, determination of level of N-terminal fragment of the brain natriuretic peptide precursor in blood plasma.
Results. Both schemes of combined therapy comparably improved the morpho-functional parameters of the heart and quality of life. In comparison with carvedilol, nebivolol more pronouncedly increased RAS and tolerance to physical activity.
Conclusion. In patients with diastolic CHF in combination therapy, the use of nebivolol, in comparison with carvedilol, may be preferable due to the positive effect on the functional state.