Features of senile asthenia syndrome and systemic interleukin profile in elderly patients with combined glaucoma and cataract

The syndrome of senile asthenia in elderly patients with combined glaucoma and cataracts on the background of interleukin imbalance has not been practically studied. Aim. To study the features of senile asthenia syndrome and systemic interleukin profile in elderly patients with combined glaucoma and cataract. Materials and methods. In clinical conditions, the senile asthenia syndrome was studied in 220 patients aged 60–74 years with primary glaucoma combined with cataract, using the questionnaire "Age is not a hindrance". The content of interleukins was determined in the blood by flow cytometry. Results. Senile asthenia syndrome among elderly patients with combined glaucoma and cataracts was detected in 33.1% of cases, with senile preasthenia syndrome – in 30.9% of cases. The value of the senile asthenia index is 0.53±0.07, which corresponds to severe senile asthenia. The formation of senile asthenia in the examined patients with comorbid ophthalmic diseases is mainly due to the presence of chronic diseases, low self-esteem of their own health and inability to walk fast. Changes in the systemic interleukin profile in elderly patients with glaucoma and cataracts are characterized by hyper-production of anti-inflammatory interleukins and, above all, blood interleukins 17 and 2, as well as a significant decrease in the content of anti-inflammatory interleukins. Conclusion. Therefore, the presence of senile asthenia syndrome in elderly patients with glaucoma and cataracts is associated with an imbalance of interleukin status.