Open AccessSkin reactions to cardiac drugs: a clinical case
Author(s) -
З. А. Невозинская,
З. А. Невозинская,
А. Л. Пирузян,
И. М. Корсунская
Publication year - 2020
Publication title -
consilium medicum
Language(s) - English
Resource type - Journals
eISSN - 2542-2170
pISSN - 2075-1753
DOI - 10.26442/20751753.2020.10.200267
Subject(s) - phototoxicity , photosensitizer , acne , drug , medicine , isotretinoin , pharmacology , dermatology , chemistry , photochemistry , biochemistry , in vitro
Drug-induced photodermatitis is an important problem in a doctor's practice. This is due to the fact that a number of drugs widely used in medicine can cause the development of photodermatitis - antibiotics and sulfonamides, non-steroidal anti-inflammatory drugs, antineoplastic drugs, diuretics, antihypertensive and antiarrhythmic drugs, antidiabetic and psychiatric drugs, tretinoin and isotretinoin, as well as some others. Drug-induced photodermatitis proceeds as phototoxic reactions. In this situation, medicinal substances in the skin can act as a photosensitizer. The pathological mechanism of development of phototoxic reactions involves both an accumulation in the skin of a substance that possess effect of a photosensitizer and the simultaneous effect of solar radiation on the skin. The photosensitizer causes rashes by increasing skin sensitivity to visible or ultraviolet part of the spectrum. This article describes the case of a 64-year-old patient who developed photodermatitis while taking amiodarone for a long time.