Open AccessFeatures of antihypertensive and vasoprotective efficiency of combination of valsartan and amlodipine in patients with obesity under different polymorphic variants of CYP2C9 and CYP11B2 genes
Author(s) -
F. A. Kovalenko,
Коваленко Фёдор Андреевич,
V. V. Skibitsky,
Скибицкий Виталий Викентьевич,
А. В. Фендрикова,
Фендрикова Александра Вадимовна
Publication year - 2018
Publication title -
sistemnye gipertenzii
Language(s) - English
Resource type - Journals
eISSN - 2542-2189
pISSN - 2075-082X
DOI - 10.26442/2075082x.2018.4.180074
Subject(s) - valsartan , vasoprotective , amlodipine , blood pressure , body mass index , medicine , obesity , pharmacology , endocrinology , cardiology , nitric oxide
Purpose. To evaluate the efficiency of combination antihypertensive therapy with valsartan and amlodipine in patients with arterial hypertension (AH) and obesity, depending on the polymorphisms of the CYP2C9 and CYP11B2 genes. Materials and methods. In research included 80 obese patients (body mass index ≥30 kg/m2) and AH 1-2 disease blood pressure (BP) ≥140/90 mm Hg and