Open AccessEvaluation of subclinical cardiotoxicity in patients with breast cancer and arterial hypertension in two regimens of anthracycline-containing chemotherapy
Author(s) -
M. A. Saidova,
Авалян Ани Ашотовна,
Е. В. Ощепкова,
Ощепкова Елена Владимировна,
М. А. Саидова,
Саидова Марина Абдулатиповна,
В Н Шитов,
Шитов Виктор Николаевич,
Е. В. Глазкова,
Глазкова Елена Владимировна,
М. Б. Стенина,
Стенина Марина Борисовна,
И. Е. Чазова,
Чазова Ирина Евгеньевна
Publication year - 2018
Publication title -
sistemnye gipertenzii
Language(s) - English
Resource type - Journals
eISSN - 2542-2189
pISSN - 2075-082X
DOI - 10.26442/2075082x.2018.4.000021
Subject(s) - anthracycline , cardiotoxicity , medicine , chemotherapy , doxorubicin , cumulative dose , breast cancer , subclinical infection , epirubicin , troponin t , troponin , cancer , cardiology , oncology , myocardial infarction
Objective. To study of subclinical cardiotoxicity of two anthracycline-containing chemotherapy regimens in breast cancer patients with normotension and arterial hypertension. Materials and methods. 119 women (mean age 48,8±10,9 years) with triple negative breast cancer were enrolled. They are received one of two chemotherapy options that differed in the intensity and duration of treatment, including the total dose of anthracyclines. Depending on the chemotherapy option, the patients were divided into two groups: group 1 (n=54) - treatment duration ≤8 weeks, cumulative dose of doxorubicin was 200 mg/m2, group 2 (n=65) - treatment duration ≤16 weeks, the cumulative dose of doxorubicin was 320 mg/m2. Before and after chemotherapy completion of all patients, the level of troponin T (h.s.) and NT-proBNP was determined, and heart ultrasound was performed, 2D and 3D speckle tracking imaging. Results. In patients who received a higher cumulative dose of doxorubicin (group 2), a statistically significant increase in biomarkers of myocardial damage was observed (h.s. troponin T before chemotherapy was 7.8±0.5 pg/ml, after chemotherapy - 55.0±7.0 pg/ml, p