Open AccessMarkers of early cardiotoxicity in patients with breast cancer undergoing chemotherapy depending on blood pressure level
Author(s) -
M. A. Saidova,
Авалян Ани Ашотовна,
M. Kirillova,
Кириллова Мария Юрьевна,
В Н Шитов,
Шитов Виктор Николаевич,
Ye V Oshchepkova,
Ощепкова Елена Владимировна,
М. А. Саидова,
Саидова Марина Абдулатиповна,
М. Б. Стенина,
Стенина Марина Борисовна,
I. Chazova,
Чазова Ирина Евгеньевна
Publication year - 2017
Publication title -
sistemnye gipertenzii
Language(s) - English
Resource type - Journals
eISSN - 2542-2189
pISSN - 2075-082X
DOI - 10.26442/2075-082x_14.3.21-27
Subject(s) - cardiotoxicity , medicine , ejection fraction , breast cancer , chemotherapy , anthracycline , cardiology , speckle tracking echocardiography , epirubicin , cancer , blood pressure , oncology , radiology , heart failure
Objective. To study the possibility of the 2D Speckle Tracking Imaging in early detection of cardiotoxicity in patients with triple negative breast cancer and arterial hypertension (AH) during anthracycline-containing chemotherapy. Materials and methods. 70 women (mean age 48.6±13.3 years) with triple negative breast cancer were enrolled. All patients underwent chemotherapy, including anthracycline, taxan, platinum-based agent. Echocardiography, including 2D Speckle Tracking Imaging, was performed on Vivid-E 9 ultrasound machine before and after 8 weeks of chemotherapy. Left ventricular ejection fraction (LVEF) (the biplane Simpson`s method) and global longitudinal strain (GLS) (mean normal GLS of -22.1±1.8 for women) were analysed. Patients were divided into two groups: group 1 - with AH (n=18) and group 2 - with normal blood pressure (n=52). Results. Before chemotherapy in group 1 GLS was lower than normal value (-19.1±2.8% vs -22.1±1.8%; p0.05). After chemotherapy in all patients GLS decrease was observed from -20.0±2.8% to -18.5±2.9% (p