Open AccessModern view on the complement system role in membranous nephropathy
Author(s) -
Elena S. Kamyshova,
Tatyana A. Semeryuk,
Irina Bobkova
Publication year - 2022
Publication title -
terapevtičeskij arhiv
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.181
H-Index - 14
eISSN - 2309-5342
pISSN - 0040-3660
DOI - 10.26442/00403660.2022.06.201563
Subject(s) - membranous nephropathy , complement system , complement membrane attack complex , alternative complement pathway , classical complement pathway , podocyte , complement (music) , medicine , immunology , nephrotic syndrome , immune system , complement receptor , lectin pathway , microbiology and biotechnology , glomerulonephritis , proteinuria , biology , kidney , biochemistry , phenotype , complementation , gene
Membranous nephropathy (MN), an immune-mediated glomerular disease, is the most common cause of adult nephrotic syndrome. In MN, proteinuria is developed by podocyte damage due to the complement system activation in response to the subepithelial deposition of immune complexes containing various auto- and exogenous antigens. Membrane-attacking complex (MAC) is the terminal product of any complement pathways activation (classical, lectin or alternative) and plays the leading role in the complement-mediated podocytic damage. Thus far, the main pathway of complement activation leading to the formation of MAC in MN has not been established. The review highlights current evidence of various complement pathways activation in the development of MN, as well as recently established new molecular mechanisms of complement-mediated podocyte damage.