Open AccessPrimary hyperparathyroidism and vitamin D deficiency
Author(s) -
Г. Е. Рунова,
Рунова Гюзель Евгеньевна,
О. О. Голоунина,
Голоунина Ольга Олеговна,
И. В. Глинкина,
Глинкина Ирина Владимировна,
В. В. Фадеев,
Фадеев Валентин Викторович
Publication year - 2021
Publication title -
terapevtičeskij arhiv
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.181
H-Index - 14
eISSN - 2309-5342
pISSN - 0040-3660
DOI - 10.26442/00403660.2021.10.201081
Subject(s) - medicine , vitamin d deficiency , primary hyperparathyroidism , vitamin d and neurology , parathyroid hormone , hyperparathyroidism , endocrine disease , hypoparathyroidism , pathological , endocrinology , diabetes mellitus , endocrine system , parathyroidectomy , disease , hormone , calcium
Primary hyperparathyroidism (PHPT) is the third most common endocrine disease after diabetes mellitus and thyroid pathology. Recent epidemiological and experimental data have shown that long-term maintenance of low vitamin D levels in the blood can lead to the development of hyperplastic processes in the cells of the parathyroid glands, followed by autonomous production of parathyroid hormone. In PHPT vitamin D insufficiency or deficiency according to various sources occurs with a frequency of 5377% of cases. The literature review indicates more severe disease in patients with concomitant vitamin D deficiency. The expediency of preoperative assessment of vitamin D levels in all patients with PHPT in order to minimize the risk of hypocalcemia after parathyroidectomy is discussed. This article presents the relationship between vitamin D deficiency and PHPT, as well as possible methods for correcting vitamin D deficiency in PHPT. Molecular and cellular mechanisms of the occurrence of pathological processes in the parathyroid glands under conditions of low vitamin D levels are presented.